On the morning of June 15, 2007, Martel died at her mother's residence in McCalla, Alabama, near Birmingham. She was 49 years old. On June 19, 2007, police confirmed that Martel did not die of natural causes, but foul play was not suspected. Based on what was known, Martel had gone to bed at her mother's home (where she was living recently) because she was not feeling well. Her husband found her unresponsive later that afternoon. Martel's sister Vickie claimed Martel died while drinking coffee with her mother on the front porch of her mother's home. Vickie suspected Sherri was taking some sort of medication/drug for her heart.
A cause of death for Martel was not initially known due to the autopsy and toxicology reports needing five to six months to complete, but on September 11, 2007, homicide investigators in Tuscaloosa, Alabama released their report stating that she died of an accidental overdose with multiple drugs in her system, including high amounts of oxycodone.
Martel's funeral was paid for by Vince McMahon while Booker T contributed the money to pay for the headstone for her grave. Her funeral was attended by wrestling friends, including Shawn Michaels, Marty Jannetty, Madusa, Sharmell Sullivan, Booker T, and Jake Roberts.